Safety & Concerns

Clinical evidence on kidneys, liver, hair, dehydration, and long-term safety. 15 articles.

• 12 Creatine Myths Debunked by Peer-Reviewed Research — 12 common creatine myths debunked with citations from peer-reviewed research. Kidney damage, hair loss, dehydration, steroid claims, and more addressed with...
• Creatine and Bloating: Water Retention vs. Gastrointestinal Issues — Distinguishing between creatine-related water retention and GI discomfort. Evidence on intracellular water retention, dosing strategies, and minimizing...
• Creatine and Blood Sugar: Research in Type 2 Diabetes — Research evidence on creatine supplementation and glycemic control. Studies in type 2 diabetic patients show potential benefits for blood sugar management...
• Creatine and Dehydration: The Myth That Won't Die — Evidence review on creatine and hydration status. Controlled studies show creatine does not cause dehydration and may actually improve thermoregulation...
• Creatine and Hair Loss: The DHT Study That Started the Myth — Critical analysis of the single 2009 study linking creatine to DHT levels. No study has measured or reported actual hair loss from creatine supplementation.
• Creatine and Heart Health: Cardiovascular Research Summary — Research summary on creatine supplementation and cardiovascular health. Evidence on blood pressure, lipid profiles, homocysteine, and cardiac function markers.
• Creatine and Kidney Health: Clinical Evidence in Healthy Adults — Clinical evidence on creatine supplementation and kidney function. Analysis of renal biomarkers, GFR data, and long-term follow-ups in healthy adults.
• Creatine and Liver Function: What Blood Tests Actually Show — Analysis of hepatic function markers in creatine users. Liver enzyme data (ALT, AST, GGT) from controlled clinical trials and long-term supplementation studies.
• Creatine and Medication Interactions: What Your Doctor Should Know — Evidence-based review of creatine interactions with common medications including NSAIDs, diuretics, nephrotoxic drugs, and diabetic medications. Clinical...
• Creatine and Muscle Cramps: What the Evidence Actually Shows — Controlled evidence on creatine supplementation and muscle cramping. Studies show creatine does not increase cramping risk and may actually reduce it in...
• Creatine During Pregnancy: Current Research and Unknowns — Current research on creatine supplementation during pregnancy. Animal studies show fetal neuroprotection potential. Human evidence is insufficient for...
• Creatine Long-Term Safety: 5-Year Follow-Up Data — Long-term safety data on creatine supplementation from multi-year follow-up studies. Comprehensive metabolic panels, organ function, and health markers over...
• Creatine Safety: The Complete Evidence-Based Guide — The most comprehensive evidence-based guide to creatine safety. Covers kidneys, liver, heart, hair, dehydration, pregnancy, drug interactions, and long-term...
• Creatine Supplementation and Creatinine: Why Your Lab Results Look High — Why creatine supplementation raises serum creatinine and falsely lowers eGFR on blood tests. How to get accurate kidney function results while taking creatine.
• Is Creatine Safe? What 500+ Studies Over 30 Years Tell Us — Comprehensive safety review of creatine monohydrate based on over 500 peer-reviewed studies spanning three decades. Evidence from clinical trials,...