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Safety & Concerns

Clinical evidence on kidneys, liver, hair, dehydration, and long-term safety.

12 Creatine Myths Debunked by Peer-Reviewed Research

12 common creatine myths debunked with citations from peer-reviewed research. Kidney damage, hair loss, dehydration, steroid claims, and more addressed with...

Creatine and Bloating: Water Retention vs. Gastrointestinal Issues

Distinguishing between creatine-related water retention and GI discomfort. Evidence on intracellular water retention, dosing strategies, and minimizing...

Creatine and Blood Sugar: Research in Type 2 Diabetes

Research evidence on creatine supplementation and glycemic control. Studies in type 2 diabetic patients show potential benefits for blood sugar management...

Creatine and Dehydration: The Myth That Won't Die

Evidence review on creatine and hydration status. Controlled studies show creatine does not cause dehydration and may actually improve thermoregulation...

Creatine and Hair Loss: The DHT Study That Started the Myth

Critical analysis of the single 2009 study linking creatine to DHT levels. No study has measured or reported actual hair loss from creatine supplementation.

Creatine and Heart Health: Cardiovascular Research Summary

Research summary on creatine supplementation and cardiovascular health. Evidence on blood pressure, lipid profiles, homocysteine, and cardiac function markers.

Creatine and Kidney Health: Clinical Evidence in Healthy Adults

Clinical evidence on creatine supplementation and kidney function. Analysis of renal biomarkers, GFR data, and long-term follow-ups in healthy adults.

Creatine and Liver Function: What Blood Tests Actually Show

Analysis of hepatic function markers in creatine users. Liver enzyme data (ALT, AST, GGT) from controlled clinical trials and long-term supplementation studies.

Creatine and Medication Interactions: What Your Doctor Should Know

Evidence-based review of creatine interactions with common medications including NSAIDs, diuretics, nephrotoxic drugs, and diabetic medications. Clinical...

Creatine and Muscle Cramps: What the Evidence Actually Shows

Controlled evidence on creatine supplementation and muscle cramping. Studies show creatine does not increase cramping risk and may actually reduce it in...

Creatine During Pregnancy: Current Research and Unknowns

Current research on creatine supplementation during pregnancy. Animal studies show fetal neuroprotection potential. Human evidence is insufficient for...

Creatine Long-Term Safety: 5-Year Follow-Up Data

Long-term safety data on creatine supplementation from multi-year follow-up studies. Comprehensive metabolic panels, organ function, and health markers over...

Creatine Safety: The Complete Evidence-Based Guide

The most comprehensive evidence-based guide to creatine safety. Covers kidneys, liver, heart, hair, dehydration, pregnancy, drug interactions, and long-term...

Creatine Supplementation and Creatinine: Why Your Lab Results Look High

Why creatine supplementation raises serum creatinine and falsely lowers eGFR on blood tests. How to get accurate kidney function results while taking creatine.

Is Creatine Safe? What 500+ Studies Over 30 Years Tell Us

Comprehensive safety review of creatine monohydrate based on over 500 peer-reviewed studies spanning three decades. Evidence from clinical trials,...

The Creatine Encyclopedia

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